Is more sedating
The resulting sedation can impair arousal levels during the day and increase the risk of falls.
Double-blind, placebo-controlled study of modafinil for fatigue and cognition in schizophrenia patients treated with psychotropic medications. Compared with younger patients, older patients receiving the same doses of the same medications become more heavily sedated for longer periods of time.
Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds.
Electroencephalographic sleep abnormalities in schizophrenia. Relationship to positive/negative symptoms and prior neuroleptic treatment.
Intramuscular aripiprazole for the treatment of acute agitation in patients with schizophrenia or schizoaffective disorder: a double-blind, placebo-controlled comparison with intramuscular haloperidol. Antipsychotics’ sedative effects can reduce agitation in acute psychosis and promote sleep in insomnia, but long-term sedation may: Many patients experience only mild, transient somnolence at the beginning of antipsychotic treatment, and most develop some tolerance to the sedating effects with continued administration. Early-onset hypothesis of antipsychotic drug action: a hypothesis tested, confirmed and extended. Manage, don’t accept adverse ‘calming’ effect Sedation is a frequent side effect of antipsychotics, especially at relatively high doses. Sedation is especially common in elderly patients receiving antipsychotics. Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected.
Others may have persistent daytime sedation that interferes with normal functioning.
Four SGAs—risperidone, olanzapine, quetiapine, and ziprasidone—act as dopamine D2 and 5HT2A antagonists.